Febrifugine dihydrochloride
| Code | Size | Price |
|---|
| TAR-TN1012L-5mg | 5mg | £184.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Febrifugine dihydrochloride is a biochemical with therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases.
CAS:
32434-42-7
Formula:
C16H21Cl2N3O3
Molecular Weight:
374.26
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
Cl.Cl.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2ccccc2c1=O
Target:
Parasite
References
Jiang S, Zeng Q, Gettayacamin M, Tungtaeng A, Wannaying S, Lim A, Hansukjariya P, Okunji CO, Zhu S, Fang D. Antimalarial activities and therapeutic properties of febrifugine analogs. Antimicrob Agents Chemother. 2005 Mar;49(3):1169-76. PubMed PMID: 15728920; PubMed Central PMCID: PMC549280.
Smullen S, McLaughlin NP, Evans P. Chemical synthesis of febrifugine and analogues. Bioorg Med Chem. 2018 May 15;26(9):2199-2220. doi: 10.1016/j.bmc.2018.04.027. Epub 2018 Apr 12. Review. PubMed PMID: 29681487.
Kikuchi H, Horoiwa S, Kasahara R, Hariguchi N, Matsumoto M, Oshima Y. Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial. Eur J Med Chem. 2014 Apr 9;76:10-9. doi: 10.1016/j.ejmech.2014.01.036. Epub 2014 Jan 25. PubMed PMID: 24565569.