TargetMol

Irisolidone

Product Code:
 
TAR-TN1035
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1035-1mg1mg£168.00
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TAR-TN1035-5mg5mg£294.00
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TAR-TN1035-1mL1 mL * 10 mM (in DMSO)£298.00
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TAR-TN1035-10mg10mg£409.00
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TAR-TN1035-25mg25mg£623.00
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TAR-TN1035-50mg50mg£839.00
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Quantity:
TAR-TN1035-100mg100mg£1,107.00
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Further Information

Bioactivity:
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
CAS:
2345-17-7
Formula:
C17H14O6
Molecular Weight:
314.293
Pathway:
Membrane transporter/Ion channel; NF-κb; Immunology/Inflammation
Purity:
0.9941
SMILES:
COc1ccc(cc1)-c1coc2cc(O)c(OC)c(O)c2c1=O
Target:
IL Receptor; NF-κB; Chloride channel

References

Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.Pflugers Arch. 2018 Jun 30. Geum-Dan, Kang, Sang-Yoon, et al. Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils[J]. Molecular Nutrition & Food Research, 2016.