TargetMol

Groenlandicine

Product Code:
 
TAR-TN1037
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1037-1mg1mg£195.00
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TAR-TN1037-5mg5mg£450.00
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TAR-TN1037-10mg10mg£616.00
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TAR-TN1037-25mg25mg£863.00
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TAR-TN1037-50mg50mg£1,179.00
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TAR-TN1037-100mg100mg£1,589.00
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Further Information

Bioactivity:
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage;Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavenging and good ROS inhibitory capacities.
CAS:
38691-95-1
Formula:
C19H16NO4
Molecular Weight:
322.339
Pathway:
DNA Damage/DNA Repair
Purity:
0.9903
SMILES:
COc1cc-2c(CC[n+]3cc4c5OCOc5ccc4cc-23)cc1O
Target:
Topoisomerase

References

Research on bitter components from Coptis chinensis based on electronic tongue.Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(17):3326-9.