Onjisaponin B
Code | Size | Price |
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TAR-TN1140-1mg | 1mg | £135.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1140-5mg | 5mg | £223.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1140-10mg | 10mg | £294.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1140-1mL | 1 mL * 10 mM (in DMSO) | £406.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1140-25mg | 25mg | £447.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1140-50mg | 50mg | £624.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TN1140-100mg | 100mg | £860.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α?-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.
CAS:
35906-36-6
Formula:
C75H112O35
Molecular Weight:
1573.686
Pathway:
Autophagy; PI3K/Akt/mTOR signaling; Chromatin/Epigenetic
Purity:
0.992
SMILES:
COc1ccc(C=CC(=O)O[C@@H]2[C@H](C)O[C@H](OC(=O)[C@@]34CCC(C)(C)C[C@@H]3C3=CC[C@@H]5[C@]6(C)C[C@H](O)[C@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]7O)[C@](C)([C@@H]6CC[C@@]5(C)C3(CO)CC4)C(O)=O)[C@@H](O[C@H]3O[C@H](C)[C@@H](O[C@H]4OC[C@@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H]3O)[C@@H]2O[C@H]2O[C@H](C)[C@H](O)[C@H](O)[C@@H]2O)cc1
Target:
AMPK; mTOR; Autophagy
References
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant ??-synuclein and huntingtin in PC-12 cells.Int J Mol Sci. 2013 Nov 15;14(11):22618-41.