TargetMol

Arnicolide D

Product Code:
 
TAR-TN1405
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1405-1mg1mg£195.00
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TAR-TN1405-5mg5mg£450.00
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TAR-TN1405-10mg10mg£616.00
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TAR-TN1405-25mg25mg£863.00
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TAR-TN1405-50mg50mg£1,179.00
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Further Information

Bioactivity:
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.
CAS:
34532-68-8
Formula:
C19H24O5
Molecular Weight:
332.396
Pathway:
Proteases/Proteasome; Apoptosis; Stem Cells; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Cytoskeletal Signaling
Purity:
0.9666
SMILES:
C[C@H]1[C@@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@H]2OC(=O)C(C)=C)OC1=O
Target:
Akt; Caspase; PI3K; STAT; mTOR

References

Huang X, et al. Cytotoxic activity of two natural sesquiterpene lactones, isobutyroylplenolin and arnicolide D, on human colon cancer cell line HT-29. Nat Prod Res. 2014;28(12):914-6.