Gentianine
| Code | Size | Price |
|---|
| TAR-TN1681-1mg | 1mg | £217.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
CAS:
439-89-4
Formula:
C10H9NO2
Molecular Weight:
175.187
Pathway:
DNA Damage/DNA Repair; Apoptosis; Metabolism
Purity:
0.98
SMILES:
C=Cc1cncc2C(=O)OCCc12
Target:
TNF; transporter; PPAR
References
Kwak WJ, et al. Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS). Biol Pharm Bull. 2005;28(4):750-753.
Wang N, et al. Machine learning enables discovery of Gentianine targeting TLR4/NF-?B pathway to repair ischemic stroke injury. Pharmacol Res. 2021;173:105913.
Vaidya H, et al. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-? gene expression in 3T3-L1 cells. Phytother Res. 2013;27(4):624-627.