TargetMol

Taccalonolide A

Product Code:
 
TAR-TN2254
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN2254-5mg5mg£159.00
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Quantity:
TAR-TN2254-1mL1 mL * 10 mM (in DMSO)£203.00
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Further Information

Bioactivity:
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.
CAS:
108885-68-3
Formula:
C36H46O14
Molecular Weight:
702.75
Pathway:
Cytoskeletal Signaling; Apoptosis
Purity:
0.9816
SMILES:
[H][C@@]12[C@H](OC(C)=O)[C@@]3([H])[C@]4([H])[C@@H](O)C(=O)[C@@]5([H])C[C@@H]6O[C@@H]6[C@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(C)[C@@]1([H])[C@H](C)C=C1OC(=O)[C@@](C)(O)[C@]21C
Target:
Apoptosis; Microtubule Associated

References

Li J , Risinger A L , Mooberry S L . Taccalonolide microtubule stabilizers[J]. Bioorganic & Medicinal Chemistry, 2014, 22(18):5091-5096.