TargetMol

Tetrahydroalstonine

Product Code:
 
TAR-TN2267
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN2267-1mL1 mL * 10 mM (in DMSO)£426.00
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TAR-TN2267-5mg5mg£528.00
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Further Information

Bioactivity:
Tetrahydroalstonine and Raubasine preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to exogenous and endogenouse noradrenaline, respectively.
CAS:
6474-90-4
Formula:
C21H24N2O3
Molecular Weight:
352.434
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.98
SMILES:
[H][C@@]12C[C@]3([H])C(=CO[C@@H](C)[C@]3([H])CN1CCc1c2[nH]c2ccccc12)C(=O)OC
Target:
Adrenergic Receptor

References

Liao Y, et al. The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation. Molecules. 2023 ; 28(5):2370. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 ; 106(1):203-205. Roquebert J, et al. Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat. J Pharmacol. 1985 ; 16(4):412-420. Malik S. Tetrahydroalstonine from Fruits of Rhazya stricta. Planta Med. 1984 ; 50(3):283.