TargetMol

Tetramethylcurcumin

Product Code:
 
TAR-TN2269
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN2269-5mg5mg£148.00
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TAR-TN2269-10mg10mg£209.00
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TAR-TN2269-1mL1 mL * 10 mM (in DMSO)£246.00
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TAR-TN2269-50mg50mg£419.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also inhibits colony formation in soft agar, cell invasion, and exhibit synergy with the anti-cancer drug doxorubicin against breast cancer cells.
CAS:
52328-97-9
Formula:
C25H28O6
Molecular Weight:
424.493
Pathway:
Apoptosis; JAK/STAT signaling; Stem Cells
Purity:
0.9994
SMILES:
COc1ccc(C=CC(=O)C(C)(C)C(=O)C=Cc2ccc(OC)c(OC)c2)cc1OC
Target:
Apoptosis; STAT

References

Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol. 2014 Jul;21(1):128-36. Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15;70(6):2445-54.