TargetMol

Capsiate

Product Code:
 
TAR-TN2429
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Capsiate is a non-pungent analogue of capsaicin with a similar biological profile. It has a role as an anti-allergic agent, a plant metabolite, an antioxidant, an angiogenesis inhibitor, a hypoglycemic agent, an anti-inflammatory agent and a capsaicin receptor agonist. It is a monomethoxybenzene, a carboxylic ester, and a member of phenols.
CAS:
205687-01-0
Formula:
C18H26O4
Molecular Weight:
306.402
Pathway:
Membrane transporter/Ion channel|oxidation-reduction
Purity:
0.98
SMILES:
COc1cc(COC(=O)CCCCC=CC(C)C)ccc1O
Target:
Antioxidant|TRP/TRPV Channel

References

Iida T, et al. TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology. 2003;44(7):958-967. Pyun BJ, et al. Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res. 2008;68(1):227-235. Lee, et al. Capsiate Inhibits DNFB-Induced Atopic Dermatitis in NC/Nga Mice through Mast Cell and CD4+ T-Cell Inactivation. J Invest Dermatol. 2015;135(8):1977-1985. Haramizu S, et al. Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice. Biomed Res. 2011;32(4):279-28