Boehmenan
| Code | Size | Price |
|---|
| TAR-TN3525-1mg | 1mg | £292.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
(?)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.
CAS:
57296-22-7
Formula:
C40H40O12
Molecular Weight:
712.8
Pathway:
Angiogenesis; MAPK; Metabolism; JAK/STAT signaling; Proteases/Proteasome; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors; DNA Damage/DNA Repair; Stem Cells
Purity:
0.98
SMILES:
COc1cc(CCCOC(=O)C=Cc2ccc(O)c(OC)c2)cc2[C@@H](COC(=O)C=Cc3ccc(O)c(OC)c3)[C@@H](Oc12)c1ccc(O)c(OC)c1
Target:
ERK; Phosphatase; EGFR; PARP; MEK; Wnt/beta-catenin; Akt; Caspase; STAT; p53