Eupatolide
| Code | Size | Price |
|---|
| TAR-TN4038-1mg | 1mg | £309.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.
CAS:
6750-25-0
Formula:
C15H20O3
Molecular Weight:
248.32
Pathway:
Tyrosine Kinase/Adaptors; Immunology/Inflammation; DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Autophagy; Apoptosis; Angiogenesis; GPCR/G Protein; Neuroscience; Cytoskeletal Signaling; NF-κb; PI3K/Akt/mTOR signaling; MAPK
Purity:
0.98
SMILES:
C=C1[C@]2([C@](OC1=O)(/C=C(C)/CC/C=C(C)/C[C@H]2O)[H])[H]
Target:
TNF; NOS; NF-κB; ROS; MAPK; Akt; COX; DNA/RNA Synthesis; Nrf2; PDGFR; NO Synthase; Prostaglandin Receptor; Autophagy
References
Lee J, et al. Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. Eur J Pharmacol. 2010 Jun 25;636(1-3):173-80.
Wu XD, et al. Bioactive sesquiterpenoids from the flowers of Inula japonica. Phytochemistry. 2016 Sep;129:68-76.