Hardwickiic acid
| Code | Size | Price |
|---|
| TAR-TN4183-5mg | 5mg | £1,259.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN4183-1mL | 1 mL * 10 mM (in DMSO) | £1,651.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic acid shows antimicrobial activity, it can inhibit the growth of all the tested microbial species. (-)-Hardwickiic acid has insecticidal activity.
CAS:
1782-65-6
Formula:
C20H28O3
Molecular Weight:
316.4
Pathway:
Cytoskeletal Signaling; Microbiology/Virology; Metabolism
Purity:
0.98
SMILES:
C[C@@H]1CC[C@]2(C)[C@H](CCC=C2C(O)=O)[C@@]1(C)CCc1ccoc1
Target:
HSP; Antifection
References
de S Vargas F, et al. Biological Activities and Cytotoxicity of Diterpenes from Copaifera spp. Oleoresins. Molecules. 2015 ; 20(4):6194-6210.
Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 ; 10(3):1716-1728.
Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic acid from Croton aromaticus. Planta Med. 1987 Dec ; 53(6):575.
Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 ; 62(4):354-359.
Kuete V, et al. Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae). J Ethnopharmacol. 2007 ; 114(1):54-60.