TargetMol

Shizukaol B

Product Code:
 
TAR-TN5011
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-TN5011-1mg1mg£325.00
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Further Information

Bioactivity:
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.
CAS:
142279-40-1
Formula:
C40H44O13
Molecular Weight:
732.77
Pathway:
NF-κb; DNA Damage/DNA Repair; GPCR/G Protein; Cell Cycle/Checkpoint; Microbiology/Virology; MAPK; Immunology/Inflammation; Neuroscience; Proteases/Proteasome; Apoptosis
Purity:
0.98
SMILES:
COC(=O)C(C)=C1[C@H]2C3=C(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@]6(O)COC(=O)C(C)=CCOC(=O)CCC(=O)OCC7=C(C[C@H]56)[C@@]24OC7=O)[C@H]2C[C@H]2[C@]3(C)[C@@H](O)C1=O
Target:
ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK