K-(D-1-Nal)-FwLL-NH2
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
CAS:
1394288-22-2
Formula:
C51H67N9O6
Molecular Weight:
902.13
Purity:
0.98
SMILES:
0
References
Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID:
M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021 PMID: