TargetMol

MM 07

Product Code:
 
TAR-TP2000
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2000-1mg1mg£191.00
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Further Information

Bioactivity:
Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.
CAS:
1876450-21-3
Formula:
C67H106N22O14S3
Molecular Weight:
1539.9
Purity:
0.98
SMILES:
0

References

Brame et al (2015) Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 65 834 PMID: Yang et al (2019) A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. Br.J.Pharmacol. 176 1206 PMID: