Lei-Dab7
Code | Size | Price |
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TAR-TP2007-1mg | 1mg | £822.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
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Further Information
Bioactivity:
High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.
CAS:
1061556-49-7
Formula:
C141H236N46O39S6
Molecular Weight:
3392.06
Purity:
0.98
SMILES:
0
References
Kramar et al (2004) A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J.Neurosci. 24 5151 PMID:
Shakkottai et al (2001) Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J.Biol.Chem. 276 43145 PMID:
Kasumu et al (2012) Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem.Biol. 19 1340 PMID: