Urantide acetate(669089-53-6 free base)

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TargetMol
Product Code: TAR-TP2106L
Supplier: TargetMol
CodeSizePrice
TAR-TP2106L-1mg1mg£163.00
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TAR-TP2106L-5mg5mg£258.00
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TAR-TP2106L-10mg10mg£340.00
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TAR-TP2106L-25mg25mg£524.00
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TAR-TP2106L-50mg50mg£723.00
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TAR-TP2106L-100mg100mg£978.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
CAS:
TP2106L
Formula:
C53H70N10O14S2
Molecular Weight:
1135.31
Pathway:
GPCR/G Protein
Purity:
0.9922
SMILES:
CC([C@@H](C(O)=O)NC([C@@H]1CSSC(C)([C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N1)=O)Cc2ccc(O)cc2)=O)CCCN)=O)Cc(c[nH]3)c4c3cccc4)=O)Cc5ccccc5)=O)NC([C@H](CC(O)=O)N)=O)C)=O)C.CC(O)=O
Target:
Neurotensin Receptor

References

Carotenuto et al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965 PMID: Patacchini et al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155 PMID: