TC14012 acetate
Code | Size | Price |
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TAR-TP2112L-1mg | 1mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TP2112L-5mg | 5mg | £308.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TP2112L-10mg | 10mg | £450.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TP2112L-25mg | 25mg | £695.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TP2112L-50mg | 50mg | £946.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.
CAS:
TP2112L
Formula:
C92H144N34O21S2
Molecular Weight:
2126.47
Pathway:
GPCR/G Protein; Autophagy; Immunology/Inflammation
Purity:
0.98
SMILES:
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CSSC[C@@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC3=CC=C(C=C3)O)=O)CCCNC(N)=O)=O)CCCCN)=O)CCCNC(N)=O)=O)=O)CC4=CC=C(C=C4)O)=O)CCCNC(N)=N)=O)CCCNC(N)=O)=O)=O)CC5=CC6=CC=CC=C6C=C5)=O)CCCNC(N)=N)=O)CCCNC(N)=N.CC(O)=O
Target:
CXCR
References
St?phanie Gravel, et al. The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. J Biol Chem. 2010 Dec 3;285(49):37939-43.
H Tamamura, et al. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1897-902.