Endothelin-1 (1-15), amide, human
| Code | Size | Price |
|---|
| TAR-TP2246-1mg | 1mg | £507.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC.
CAS:
TP2246
Formula:
C70H109N17O23S5
Molecular Weight:
1717.04
Purity:
0.98
SMILES:
O=C4N[C@@]([H])(CO)C(=O)N[C@]1([H])C[S][S]C[C@@]([H])(NC(=O)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(NC1=O)CO)CO)CC(C)(C)[H])CC[S]C)CC(=O)O)CCCCN)CCC(O)=O)C(=O)N[C@@]([H])(C(=O)N[C@@]([H])(C/C2=C/C=C(/O)C=C2)C(=O)N[C@]([H])(C/C3=C/C=CC=C3)C(=O)N[C@]([H])(C[S][S]C[C@@]4(N)[H])C(=O)N[C@]([H])(CC=5N=CNC=5)C(=O)N[C@]([H])(CC(C)(C)[H])C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C(=O)N[C@]([H])(C/C6=C/NC=7C=CC=CC6=7)C(O)=O)[C@](C)([H])CC)[C@](C)([H])CC)C(C)(C)[H]
References
Kisker O, Becker CM, Prox D et al. Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model. Cancer Res. 2001 Oct 15;61(20):7669-74.
Moulton KS, Heller E, Konerding MA et al. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 1999 Apr 6;99(13):1726-32.
O'Reilly MS, Boehm T, Shing Y et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997 Jan 24;88(2):277-85.