Kamebakaurin
| Code | Size | Price |
|---|
| TAR-TWS1977-1mg | 1mg | £151.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TWS1977-5mg | 5mg | £340.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. 3. Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50.4. Kamebakaurin has anti-neuroinflammatory activity via inhibition of c-Jun NH -terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.
CAS:
73981-34-7
Formula:
C20H30O5
Molecular Weight:
350.455
Pathway:
NF-κb
Purity:
0.9805
SMILES:
CC1(C)CC[C@H](O)[C@@]2(CO)[C@@H]3CC[C@@H]4[C@H](O)[C@@]3([C@H](O)C[C@H]12)C(=O)C4=C
Target:
NF-κB
References
Wang K S , Lee J J . Kamebakaurin inhibits the expression of hypoxia-inducible factor-1? and its target genes to confer antitumor activity[J]. Oncology Reports, 2016, 35(4):2045.