Abexinostat

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TargetMol
Product Code: TAR-T0431
Supplier: TargetMol
CodeSizePrice
TAR-T0431-1mg1mg£97.00
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TAR-T0431-2mg2mg£107.00
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TAR-T0431-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T0431-5mg5mg£128.00
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TAR-T0431-10mg10mg£159.00
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TAR-T0431-25mg25mg£223.00
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TAR-T0431-50mg50mg£346.00
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TAR-T0431-100mg100mg£503.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PCI-24781 (Abexinostat) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.
CAS:
783355-60-2
Formula:
C21H23N3O5
Molecular Weight:
397.431
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9843
SMILES:
CN(C)Cc1c(oc2ccccc12)C(=O)NCCOc1ccc(cc1)C(=O)NO
Target:
HDAC

References

1. Buggy JJ, et al. Mol Cancer Ther, 2006, 5(5), 1309-1317. 2. Adimoolam S, et al. Proc Natl Acad Sci U S A, 2007, 104(49), 19482-19487. 3. Lopez G, et al. Clin Cancer Res, 2009, 15(10), 3472-3483. 4. Bhalla S, et al. Clin Cancer Res, 2009, 15(10), 3354-3365.