BIBO3304 TFA

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TargetMol
Product Code: TAR-T10539
Supplier: TargetMol
CodeSizePrice
TAR-T10539-1mg1mg£149.00
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TAR-T10539-2mg2mg£189.00
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TAR-T10539-5mg5mg£258.00
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TAR-T10539-10mg10mg£401.00
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TAR-T10539-1mL1 mL * 10 mM (in DMSO)£415.00
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TAR-T10539-25mg25mg£621.00
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TAR-T10539-50mg50mg£855.00
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TAR-T10539-100mg100mg£1,131.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).
CAS:
191868-14-1
Formula:
C31H36F3N7O5
Molecular Weight:
643.668
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9887
SMILES:
OC(=O)C(F)(F)F.NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1
Target:
Neuropeptide Y Receptor

References

1. Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125(3):549-55. 2. Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490.