Metarrestin

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TargetMol
Product Code: TAR-T12006
Supplier: TargetMol
CodeSizePrice
TAR-T12006-1mg1mg£98.00
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TAR-T12006-2mg2mg£109.00
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TAR-T12006-5mg5mg£135.00
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TAR-T12006-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T12006-10mg10mg£189.00
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TAR-T12006-25mg25mg£322.00
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TAR-T12006-50mg50mg£503.00
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TAR-T12006-100mg100mg£695.00
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TAR-T12006-500mg500mg£1,372.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
CAS:
1443414-10-5
Formula:
C31H30N4O
Molecular Weight:
474.608
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9904
SMILES:
OC1CCC(CC1)n1cnc2n(Cc3ccccc3)c(c(-c3ccccc3)c2c1=N)-c1ccccc1
Target:
DNA/RNA Synthesis

References

1. Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080. 2. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).