ML-180

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TargetMol
Product Code: TAR-T12075
Supplier: TargetMol
CodeSizePrice
TAR-T12075-1mg1mg£95.00
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TAR-T12075-2mg2mg£106.00
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TAR-T12075-5mg5mg£127.00
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TAR-T12075-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T12075-10mg10mg£164.00
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TAR-T12075-25mg25mg£246.00
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TAR-T12075-50mg50mg£377.00
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TAR-T12075-100mg100mg£535.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .
CAS:
863588-32-3
Formula:
C20H25ClN4O2
Molecular Weight:
388.9
Purity:
0.9983
SMILES:
Clc1cccc(c1)N1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1

References

1. Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2). 2. Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304.