AZ PFKFB3 26

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TargetMol
Product Code: TAR-T14365
Supplier: TargetMol
CodeSizePrice
TAR-T14365-1mg1mg£95.00
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TAR-T14365-2mg2mg£106.00
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TAR-T14365-5mg5mg£128.00
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TAR-T14365-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T14365-10mg10mg£173.00
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TAR-T14365-25mg25mg£303.00
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TAR-T14365-50mg50mg£470.00
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TAR-T14365-100mg100mg£627.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
CAS:
1704740-52-2
Formula:
C24H26N4O2
Molecular Weight:
402.498
Pathway:
Metabolism
Purity:
0.9891
SMILES:
CC(C)Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc12
Target:
Glucokinase

References

1. Boyd S, et al. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015 Apr 23;58(8):3611-25.