CLP257

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TargetMol
Product Code: TAR-T14984
Supplier: TargetMol
CodeSizePrice
TAR-T14984-1mg1mg£101.00
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TAR-T14984-2mg2mg£114.00
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TAR-T14984-5mg5mg£142.00
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TAR-T14984-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T14984-10mg10mg£185.00
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TAR-T14984-25mg25mg£310.00
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TAR-T14984-50mg50mg£464.00
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TAR-T14984-100mg100mg£651.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
CLP257 is a selective K+-Cl? cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl? transport in neurons with diminished KCC2 activity.
CAS:
1181081-71-9
Formula:
C14H14FN3O2S
Molecular Weight:
307.34
Pathway:
Membrane transporter/Ion channel
Purity:
0.9813
SMILES:
Oc1cc(F)ccc1C=C1/SC(=NC1=O)N1CCCCN1
Target:
Potassium Channel

References

1. Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8. 2. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870.