KY1220

Contact us
TargetMol
Product Code: TAR-T15677
Supplier: TargetMol
CodeSizePrice
TAR-T15677-1mg1mg£106.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-2mg2mg£122.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-1mL1 mL * 10 mM (in DMSO)£160.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-5mg5mg£168.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-10mg10mg£230.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-25mg25mg£436.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-50mg50mg£610.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T15677-100mg100mg£838.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1
❮❯

Documents

Further Information

Bioactivity:
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.
CAS:
292168-79-7
Formula:
C14H10N4O3S
Molecular Weight:
314.32
Pathway:
Cytoskeletal Signaling; Stem Cells
Purity:
0.9966
SMILES:
[O-][N+](=O)c1ccc(cc1)-n1cccc1C=C1/NC(=S)NC1=O
Target:
Wnt/beta-catenin

References

1. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes ?-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.