MS4078

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TargetMol
Product Code: TAR-T16153
Supplier: TargetMol
CodeSizePrice
TAR-T16153-1mg1mg£106.00
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TAR-T16153-2mg2mg£122.00
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TAR-T16153-5mg5mg£148.00
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TAR-T16153-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T16153-10mg10mg£201.00
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TAR-T16153-25mg25mg£303.00
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TAR-T16153-50mg50mg£442.00
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TAR-T16153-100mg100mg£619.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19?nM for binding affinity to ALK.
CAS:
2229036-62-6
Formula:
C45H52ClN9O8S
Molecular Weight:
914.48
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9874
SMILES:
CC(C)Oc1cc(C2CCN(CC(=O)NCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
Target:
ALK

References

1. Zhang C, et al. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). Eur J Med Chem. 2018 May 10;151:304-314.