Ogerin

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TargetMol
Product Code: TAR-T16378
Supplier: TargetMol
CodeSizePrice
TAR-T16378-1mg1mg£95.00
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TAR-T16378-2mg2mg£106.00
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TAR-T16378-5mg5mg£125.00
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TAR-T16378-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T16378-10mg10mg£164.00
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TAR-T16378-25mg25mg£262.00
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TAR-T16378-50mg50mg£393.00
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TAR-T16378-100mg100mg£550.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor.
CAS:
1309198-71-7
Formula:
C17H17N5O
Molecular Weight:
307.357
Pathway:
Neuroscience; ; GPCR/G Protein
Purity:
0.999
SMILES:
Nc1nc(NCc2ccccc2)nc(n1)-c1ccccc1CO
Target:
5-HT Receptor; Adenosine Receptor

References

1. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.