SJ-172550

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TargetMol
Product Code: TAR-T16888
Supplier: TargetMol
CodeSizePrice
TAR-T16888-2mg2mg£100.00
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TAR-T16888-5mg5mg£118.00
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TAR-T16888-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T16888-10mg10mg£148.00
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TAR-T16888-25mg25mg£227.00
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TAR-T16888-50mg50mg£369.00
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TAR-T16888-100mg100mg£583.00
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TAR-T16888-500mg500mg£1,139.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
CAS:
431979-47-4
Formula:
C22H21ClN2O5
Molecular Weight:
428.87
Pathway:
Apoptosis; Ubiquitination
Purity:
0.9987
SMILES:
CCOc1cc(C=C2/C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC
Target:
Mdm2; E1/E2/E3 Enzyme

References

1. Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 2;285(14):10786-96. 2. Bista M, et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012;7(6):e37518.