RITA

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TargetMol
Product Code: TAR-T1798
Supplier: TargetMol
CodeSizePrice
TAR-T1798-1mg1mg£95.00
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TAR-T1798-2mg2mg£101.00
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TAR-T1798-5mg5mg£119.00
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TAR-T1798-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T1798-10mg10mg£148.00
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TAR-T1798-25mg25mg£230.00
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TAR-T1798-50mg50mg£362.00
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TAR-T1798-100mg100mg£500.00
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TAR-T1798-200mg200mg£675.00
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TAR-T1798-500mg500mg£994.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
CAS:
213261-59-7
Formula:
C14H12O3S2
Molecular Weight:
292.37
Pathway:
DNA Damage/DNA Repair; Autophagy; Apoptosis
Purity:
0.9885
SMILES:
OCc1ccc(s1)-c1ccc(o1)-c1ccc(CO)s1
Target:
Mdm2; DNA Alkylator/Crosslinker; p53; Autophagy

References

1. Rivera MI, et al. Biochem Pharmacol. 1999, 57(11), 1283-1295. 2. Nieves-Neira W, et al. Mol Pharmacol. 1999, 56(3), 478-484. 3. Issaeva N, et al. Nat Med. 2004, 10(12), 1321-1328. 4. Ma T, et al. Biochem Biophys Res Commun. 2012, 417(3), 931-937. 5. Saha MN, et al. PLoS One. 2012, 7(1), e30215.