KPT330,(E)-

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TargetMol
Product Code: TAR-T1844
Supplier: TargetMol
CodeSizePrice
TAR-T1844-1mg1mg£99.00
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TAR-T1844-2mg2mg£109.00
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TAR-T1844-5mg5mg£128.00
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TAR-T1844-10mg10mg£145.00
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TAR-T1844-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T1844-25mg25mg£230.00
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TAR-T1844-50mg50mg£357.00
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TAR-T1844-100mg100mg£495.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
KPT330,(E)- is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.
CAS:
1421923-86-5
Formula:
C17H11F6N7O
Molecular Weight:
443.313
Pathway:
; Membrane transporter/Ion channel
Purity:
0.9926
SMILES:
FC(F)(F)c1cc(cc(c1)C(F)(F)F)-c1ncn(C=CC(=O)NNc2cnccn2)n1
Target:
CRM1

References

1. Etchin J, et al. Br J Haematol. 2013, 161(1), 117-127. 2. Tai YT, et al. Leukemia. 2014, 28(1), 155-165.