TargetMol

Dimethoxycurcumin

Product Code:
 
TAR-T19853
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19853-1mg1mg£106.00
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TAR-T19853-2mg2mg£120.00
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TAR-T19853-5mg5mg£148.00
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TAR-T19853-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-T19853-10mg10mg£195.00
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TAR-T19853-25mg25mg£306.00
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TAR-T19853-50mg50mg£483.00
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TAR-T19853-100mg100mg£670.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dimethoxycurcumin is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.
CAS:
160096-59-3
Formula:
C23H24O6
Molecular Weight:
396.439
Purity:
0.9605
SMILES:
COc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(OC)c(OC)c2)cc1OC

References

1. Zhao H, Liu Q et al. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer Med. 2017 Jul;6(7):1698-1706. 2. Teymouri M, Barati N, Pirro M, Sahebkar A. Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential. J Cell Physiol. 2018 Jan;233(1):124-140. 3. Chen D, Dai F, Chen Z et al. Dimethoxy Curcumin Induces Apoptosis by Suppressing Survivin and Inhibits Invasion by Enhancing E-Cadherin in Colon Cancer Cells. Med Sci Monit. 2016 Sep 11;22:3215-22. 4. Hassan HE, Keita JA, Narayan L, Brady SM, Frederick R, Carlson S, Glass KC, Natesan S, Buttolph T, Fandy TE. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect. Epigenetics. 2016 Sep 2:1-10. [Epub ahead of print] PubMed PMID: 27588609; PubMed Central PMCID: PMC5094623.