MLN9708

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TargetMol
Product Code: TAR-T2016
Supplier: TargetMol
CodeSizePrice
TAR-T2016-5mg5mg£105.00
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TAR-T2016-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T2016-10mg10mg£119.00
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Quantity:
TAR-T2016-25mg25mg£148.00
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Quantity:
TAR-T2016-50mg50mg£177.00
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Quantity:
TAR-T2016-100mg100mg£252.00
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TAR-T2016-200mg200mg£340.00
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TAR-T2016-500mg500mg£523.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 is MLN2238 in aqueous solutions or plasma.
CAS:
1201902-80-8
Formula:
C20H23BCl2N2O9
Molecular Weight:
517.12
Pathway:
Ubiquitination; Proteases/Proteasome
Purity:
0.9879
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O
Target:
Proteasome

References

1. Kupperman E, et al. Cancer Res, 2010, 70(5), 1970-80. 2. Chauhan D, et al. Clin Cancer Res, 2011, 17(16), 5311-21. 3. Lee EC, et al.Clin Cancer Res, 2011, 17(23),7313-23. 4. E. T. Rodler, et al. Journal of Clinical Oncology, 2010, 28(15)