GSK126
Code | Size | Price |
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TAR-T2079-2mg | 2mg | £100.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-5mg | 5mg | £118.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-1mL | 1 mL * 10 mM (in DMSO) | £125.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-10mg | 10mg | £143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-25mg | 25mg | £194.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-50mg | 50mg | £262.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-100mg | 100mg | £366.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2079-200mg | 200mg | £455.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GSK126 is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).
CAS:
1346574-57-9
Formula:
C31H38N6O2
Molecular Weight:
526.67
Pathway:
Chromatin/Epigenetic
Purity:
0.9967
SMILES:
CC[C@H](C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Target:
Histone Methyltransferase
References
1. McCabe MT, et al. Nature. 2012, 492(7427), 108-112.
2. Ott HM, et al. Mol Cancer Ther. 2014, 13(12), 3062-3073.
3. Takeshima H, et al. Carcinogenesis. 2015, 36(2), 192-201.
4. Huang H, Wu D, Yan Y, et al. A targetable epigenetic vulnerability in PI3K/AKT inhibitor resistant cancers[J]. bioRxiv. 2020
5. Wu D, Yan Y, Wei T, et al. An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors[J]. Cell Reports . 2021, 34(7): 108744.