CP-31398 dihydrochloride

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TargetMol
Product Code: TAR-T21648
Supplier: TargetMol
CodeSizePrice
TAR-T21648-1mg1mg£95.00
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TAR-T21648-2mg2mg£106.00
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TAR-T21648-5mg5mg£127.00
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TAR-T21648-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T21648-10mg10mg£164.00
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TAR-T21648-25mg25mg£252.00
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TAR-T21648-50mg50mg£362.00
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TAR-T21648-100mg100mg£547.00
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TAR-T21648-200mg200mg£748.00
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TAR-T21648-500mg500mg£1,075.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
CP 31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
CAS:
1217195-61-3
Formula:
C22H28Cl2N4O
Molecular Weight:
435.39
Pathway:
Apoptosis
Purity:
0.9953
SMILES:
Cl.Cl.COc1ccc(C=Cc2nc(NCCCN(C)C)c3ccccc3n2)cc1
Target:
p53

References

1. Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1(1):47-55. 2. B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10.