TargetMol

L-745870 trihydrochloride

Product Code:
 
TAR-T22904
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22904-1mg1mg£125.00
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TAR-T22904-2mg2mg£149.00
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TAR-T22904-5mg5mg£189.00
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TAR-T22904-10mg10mg£241.00
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TAR-T22904-25mg25mg£462.00
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TAR-T22904-50mg50mg£630.00
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TAR-T22904-100mg100mg£863.00
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TAR-T22904-500mg500mg£1,661.00
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Further Information

Bioactivity:
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. L-745870 trihydrochloride exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors and shows weaker affinity for D2 and D3 receptors.
CAS:
866021-03-6
Formula:
C18H22Cl4N4
Molecular Weight:
436.2
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
Cl.Cl.Cl.Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1
Target:
Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor

References

1. Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8. 2. Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.