Neratinib

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TargetMol
Product Code: TAR-T2325
Supplier: TargetMol
CodeSizePrice
TAR-T2325-5mg5mg£95.00
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TAR-T2325-10mg10mg£105.00
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TAR-T2325-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T2325-25mg25mg£122.00
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TAR-T2325-50mg50mg£139.00
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TAR-T2325-100mg100mg£172.00
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TAR-T2325-200mg200mg£229.00
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TAR-T2325-500mg500mg£334.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
CAS:
698387-09-6
Formula:
C30H29ClN6O3
Molecular Weight:
557.05
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling
Purity:
0.9855
SMILES:
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)C=CCN(C)C
Target:
EGFR; HER

References

1. Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965. 2. Ji H, et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7817-22.