ANA-12

TargetMol
Product Code: TAR-T2359
Supplier: TargetMol
CodeSizePrice
TAR-T2359-1mg1mg£98.00
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TAR-T2359-2mg2mg£108.00
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TAR-T2359-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T2359-5mg5mg£128.00
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TAR-T2359-10mg10mg£168.00
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TAR-T2359-25mg25mg£232.00
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TAR-T2359-50mg50mg£369.00
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TAR-T2359-100mg100mg£511.00
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TAR-T2359-500mg500mg£1,010.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
CAS:
219766-25-3
Formula:
C22H21N3O3S
Molecular Weight:
407.49
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9987
SMILES:
O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1
Target:
Trk receptor

References

1. Cazorla M, et al. J Clin Invest. 2011, 121(5), 1846-1857. 2. Chen W, et al. Eur J Neurosci. 2014, 39(9), 1439-1454. 3. Zhang JC, et al. Int J N europsychopharmacol. 2015, 18(4), 1-12 4. Spaeth AM, et al. Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1252-60. 5. Leggio GM, et al. Neuropsychopharmacology. 2014, 39(8), 22017-2028. 6. Zhang JC, et al. Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl). 2015 Dec;232(23):4325-35. 7. Fang X, et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci. 2018 Jun 7.