Torkinib

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TargetMol
Product Code: TAR-T2414
Supplier: TargetMol
CodeSizePrice
TAR-T2414-5mg5mg£112.00
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TAR-T2414-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T2414-10mg10mg£125.00
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TAR-T2414-25mg25mg£148.00
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TAR-T2414-50mg50mg£181.00
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TAR-T2414-100mg100mg£262.00
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TAR-T2414-200mg200mg£356.00
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TAR-T2414-500mg500mg£544.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
CAS:
1092351-67-1
Formula:
C16H16N6O
Molecular Weight:
308.345
Pathway:
PI3K/Akt/mTOR signaling; Autophagy; Apoptosis
Purity:
0.9923
SMILES:
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12
Target:
Apoptosis; Mitophagy; PI3K; mTOR; Autophagy

References

1. Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. 2. Janes MR, et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med. 2010 Feb;16(2):205-13. 3. Feldman ME, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10;7(2):e38.