D4476

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TargetMol
Product Code: TAR-T2449
Supplier: TargetMol
CodeSizePrice
TAR-T2449-1mg1mg£99.00
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Quantity:
TAR-T2449-2mg2mg£111.00
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TAR-T2449-5mg5mg£128.00
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TAR-T2449-1mL1 mL * 10 mM (in DMSO)£133.00
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Quantity:
TAR-T2449-10mg10mg£140.00
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Quantity:
TAR-T2449-25mg25mg£201.00
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Quantity:
TAR-T2449-50mg50mg£262.00
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TAR-T2449-100mg100mg£415.00
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TAR-T2449-500mg500mg£863.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
CAS:
301836-43-1
Formula:
C23H18N4O3
Molecular Weight:
398.422
Pathway:
Autophagy; Tyrosine Kinase/Adaptors; Angiogenesis; Apoptosis; Metabolism; Stem Cells
Purity:
0.9996
SMILES:
NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCCOc2c1
Target:
Apoptosis; Casein Kinase; ALK; Autophagy

References

1. Rena G, et al. EMBO Rep. 2004, 5(1), 60-65. 2. Hu Y, et al. Leukemia. 2015, 29(2), 474-482. 3. J?r?s M, et al. J Exp Med. 2014,211(4), 605-612. 4. Bain J, et al. Biochem J. 2003, 371(Pt 1), 199-204.