IRAK-1-4 Inhibitor I

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TargetMol
Product Code: TAR-T2457
Supplier: TargetMol
CodeSizePrice
TAR-T2457-1mg1mg£100.00
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TAR-T2457-2mg2mg£111.00
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TAR-T2457-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T2457-5mg5mg£128.00
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TAR-T2457-10mg10mg£160.00
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TAR-T2457-25mg25mg£278.00
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TAR-T2457-50mg50mg£461.00
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TAR-T2457-100mg100mg£629.00
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TAR-T2457-500mg500mg£1,267.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.
CAS:
509093-47-4
Formula:
C20H21N5O4
Molecular Weight:
395.419
Pathway:
Immunology/Inflammation; NF-κb
Purity:
0.9989
SMILES:
[O-][N+](=O)c1cccc(c1)C(=O)Nc1nc2ccccc2n1CCN1CCOCC1
Target:
IRAK

References

1. Powers JP, et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-2845. 2. Bhattacharyya S, et al. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37. 3. Wu X, Xu M, Liu Y, et al. Dual Pharmacological Inhibition of IRAK1 and IRAK4 Prevents LPS Induced Monocyte Adhesion to Endothelial Cells[J]. bioRxiv. 2021