A-769662

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TargetMol
Product Code: TAR-T2468
Supplier: TargetMol
CodeSizePrice
TAR-T2468-2mg2mg£97.00
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TAR-T2468-5mg5mg£112.00
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TAR-T2468-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T2468-10mg10mg£128.00
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TAR-T2468-25mg25mg£187.00
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TAR-T2468-50mg50mg£287.00
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TAR-T2468-100mg100mg£466.00
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TAR-T2468-500mg500mg£930.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
CAS:
844499-71-4
Formula:
C20H12N2O3S
Molecular Weight:
360.39
Pathway:
Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Metabolism
Purity:
0.9958
SMILES:
Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12
Target:
AMPK; Fatty Acid Synthase

References

1. Cool B, et al, Cell Metab, 2006, 3(6), 403-416. 2. Sanders MJ, J Biol Chem, 2007, 282(45), 32539-32548. 3. Moreno D, et al, FEBS Lett, 2008, 583(17), 2650-2654. 4. Pevton KJ, et al, J Pharmacol Exp Ther, 2012, Jun 13. 5. Lu X Y, Shi X J, Hu A, et al. Feeding induces cholesterol biosynthesis via the mTORC1?USP20?HMGCR axis[J]. Nature. 2020, 588(7838): 479-484.