Torcetrapib

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TargetMol
Product Code: TAR-T2499
Supplier: TargetMol
CodeSizePrice
TAR-T2499-1mg1mg£100.00
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TAR-T2499-2mg2mg£111.00
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TAR-T2499-5mg5mg£128.00
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TAR-T2499-10mg10mg£149.00
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TAR-T2499-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T2499-25mg25mg£236.00
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TAR-T2499-50mg50mg£378.00
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TAR-T2499-100mg100mg£527.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to excess deaths.
CAS:
262352-17-0
Formula:
C26H25F9N2O4
Molecular Weight:
600.47
Pathway:
Metabolism
Purity:
0.9891
SMILES:
FC(F)(F)c1cc2c(N([C@@H](C[C@@H]2N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)CC)C(=O)OCC)cc1
Target:
CETP

References

1. Clark RW, et al. Arterioscler Thromb Vasc Biol, 2004, 24(3), 490-497. 2. Hu X, et al. Endocrinology, 2009, 150(5), 2211-2219. 3. Barter PJ, et al. N Engl J Med, 2007, 357(21), 2109-2122. 4. Yvan-Charvet L, et al. Arterioscler Thromb Vasc Biol, 2007, 27(5), 1132-1138. 5. Morehouse LA, et al. J Lipid Res, 2007, 48(6), 1263-1272.