Mitonafide

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TargetMol
Product Code: TAR-T25817
Supplier: TargetMol
CodeSizePrice
TAR-T25817-1mg1mg£95.00
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TAR-T25817-2mg2mg£103.00
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TAR-T25817-5mg5mg£122.00
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TAR-T25817-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T25817-10mg10mg£148.00
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TAR-T25817-25mg25mg£230.00
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TAR-T25817-50mg50mg£334.00
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TAR-T25817-100mg100mg£502.00
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TAR-T25817-200mg200mg£687.00
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TAR-T25817-500mg500mg£994.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Mitonafide suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
CAS:
54824-17-8
Formula:
C16H15N3O4
Molecular Weight:
313.313
Pathway:
Microbiology/Virology
Purity:
0.9904
SMILES:
CN(C)CCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Target:
Antibacterial

References

1. Korycka-Machala M, et al. Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli. Molecules. 2017 Jan 17;22(1). pii: E154. 2. Kumar A, et al. Solvent free, catalyst free, microwave or grinding assisted synthesis of bis-cyclic imide derivatives and their evaluation for anticancer activity. Bioorg Med Chem Lett. 2017 Feb 1;27(3):501-504. 3. Johnson CA, et al. Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. Bioorg Med Chem. 2015 Jul 1;23(13):3586-91. 4. Machado KE, et al. Apoptotic events induced by maleimides on human acute leukemia cell lines. Chem Res Toxicol. 2013 Dec 16;26(12):1904-16.