GSK2606414
Code | Size | Price |
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TAR-T2614-2mg | 2mg | £119.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2614-5mg | 5mg | £147.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2614-1mL | 1 mL * 10 mM (in DMSO) | £149.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2614-10mg | 10mg | £174.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2614-50mg | 50mg | £351.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
CAS:
1337531-36-8
Formula:
C24H20F3N5O
Molecular Weight:
451.453
Pathway:
Autophagy; Apoptosis
Purity:
0.98
SMILES:
Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12
Target:
Apoptosis; PERK; Autophagy
References
1. Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207.
2. Zhang J, Zhang P, Meng C, et al. Subarachnoid Hemorrhage. Springer, Cham. 2020: 105-119.
3. Kong F, Zou H, Liu X, et al. miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells[J]. Photodiagnosis and Photodynamic Therapy. 2020: 101663.
4. Meng C, Zhang J, Dang B, et al. PERK pathway activation promotes intracerebral hemorrhage induced secondary brain injury by inducing neuronal apoptosis both in vivo and in vitro[J]. Frontiers in neuroscience. 2018 Feb 28;12:111.