LGK974

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TargetMol
Product Code: TAR-T2618
Supplier: TargetMol
CodeSizePrice
TAR-T2618-1mg1mg£103.00
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TAR-T2618-2mg2mg£118.00
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TAR-T2618-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T2618-5mg5mg£148.00
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TAR-T2618-10mg10mg£205.00
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TAR-T2618-25mg25mg£327.00
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TAR-T2618-50mg50mg£531.00
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TAR-T2618-100mg100mg£728.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.
CAS:
1243244-14-5
Formula:
C23H20N6O
Molecular Weight:
396.454
Pathway:
Stem Cells
Purity:
0.9979
SMILES:
Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
Target:
Porcupine

References

1. Liu J, et al. Proc Natl Acad Sci U S A. 2013, 110(50), 20224-20229. 2. Jiang X, et al. Proc Natl Acad Sci U S A. 2013, 110(31), 12649-12654.