LY2811376

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TargetMol
Product Code: TAR-T2639
Supplier: TargetMol
CodeSizePrice
TAR-T2639-1mg1mg£109.00
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TAR-T2639-2mg2mg£124.00
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TAR-T2639-1mL1 mL * 10 mM (in DMSO)£171.00
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TAR-T2639-5mg5mg£171.00
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TAR-T2639-10mg10mg£244.00
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TAR-T2639-25mg25mg£386.00
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TAR-T2639-50mg50mg£544.00
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TAR-T2639-100mg100mg£748.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
CAS:
1194044-20-6
Formula:
C15H14F2N4S
Molecular Weight:
320.36
Pathway:
Neuroscience
Purity:
0.9901
SMILES:
C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1
Target:
Beta Amyloid; Beta-Secretase; BACE

References

1. May P, et al. J Neurosci, 2011, 31(46), 16507-16516. 2. Yang HC, et al. J Neurochem, 2004, 91(6), 1249-1259.