JNK-IN-8

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TargetMol
Product Code: TAR-T2668
Supplier: TargetMol
CodeSizePrice
TAR-T2668-2mg2mg£102.00
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TAR-T2668-5mg5mg£127.00
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TAR-T2668-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T2668-10mg10mg£168.00
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TAR-T2668-25mg25mg£246.00
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TAR-T2668-50mg50mg£362.00
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TAR-T2668-100mg100mg£501.00
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TAR-T2668-200mg200mg£682.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
JNK-IN-8 is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ in A375 cell line.
CAS:
1410880-22-6
Formula:
C29H29N7O2
Molecular Weight:
507.598
Pathway:
MAPK; Tyrosine Kinase/Adaptors
Purity:
0.9924
SMILES:
CN(C)CC=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1
Target:
JNK; c-Kit

References

1. Zhang T, et al. Chem Biol, 2012, 19(1), 140-154. 2. Goh ET, et al. Biochem J, 2012, 441(1), 339-346. 3. Liu Q, et al. Chem Biol, 2013, 20(2), 146-159.